United States securities and exchange commission logo July 13, 2022 Robert Gagnon Chief Business and Financial Officer Verastem, Inc. 117 Kendrick Street Suite 500 Needham, MA 02494 Re: Verastem, Inc. Form 10-K For the Year Ended 12/31/2021 File No. 001-35403 Dear Mr. Gagnon: We have completed our review of your filing. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, Division of Corporation Finance Office of Life Sciences