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Verastem Issued Japanese Patent on Dual mTORC1/2 and PI3K Inhibitor VS-5584
“This latest patent milestone underscores Verastem’s continued interest
in pursuing oncology-based development programs in Japan,” said
The PI3K/mTOR signaling pathway is a key regulator in cancer progression
and the survival of cancer stem cells. VS-5584 is a highly potent dual
inhibitor of mTORC1/2 and PI3K with relative equipotency against all
four human Class I PI3K isoforms and the mTOR kinase.
In addition to the patent issuance for VS-5584,
About VS-5584
VS-5584 is an orally available compound that has demonstrated potent and
highly selective activity against class 1 PI3K enzymes and dual
inhibitory actions against mTORC1 and mTORC2 pathways. In preclinical
studies, VS-5584 has been shown to reduce the percentage of cancer stem
cells and induce tumor regression in taxane-resistant models.
About VS-6063
VS-6063 (defactinib) is an orally available compound designed to target
cancer stem cells through the potent inhibition of focal adhesion kinase
(FAK). Cancer stem cells are an underlying cause of tumor resistance to
chemotherapy, recurrence and ultimate disease progression. Research by
About
Forward-looking statements:
This press release includes forward-looking statements about the
Company’s strategy, future plans and prospects, including statements
regarding the development of the Company’s compounds, including VS-6063,
or defactinib, and VS-5584 and the Company’s FAK, mTOR/PI3K and
diagnostic programs generally, the timeline for clinical development
including projected enrollment of trials, regulatory approval of the
Company’s compounds, the expected timing for the reporting of data from
ongoing trials and the structure of the Company’s planned or pending
clinical trials. The words “anticipate,” “appear,” “believe,”
“estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,”
“target,” “potential,” “will,” “would,” “could,” “should,” “continue,”
and similar expressions are intended to identify forward-looking
statements, although not all forward-looking statements contain these
identifying words. Each forward-looking statement is subject to risks
and uncertainties that could cause actual results to differ materially
from those expressed or implied in such statement. Applicable risks and
uncertainties include the risks that the preclinical testing of the
Company’s compounds and preliminary data from clinical trials may not be
predictive of the results or success of pending or later clinical
trials, that data may not be available when we expect it to be, that the
Company will not be able to enroll a sufficient number of patients in
the expected timeframe, that the Company will be unable to successfully
complete the clinical development of its compounds, including VS-6063
and VS-5584, that the development of the Company’s compounds will take
longer or cost more than planned, and that the Company’s compounds will
not receive regulatory approval or become commercially successful
products. Other risks and uncertainties include those identified under
the heading “Risk Factors” in the Company’s Annual Report on Form 10-K
for the year ended
Source:
Verastem, Inc.
Brian Sullivan, 617-252-9314
bsullivan@verastem.com